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Yan Luo Selected Research

Carboplatin (JM8)

1/2024Experience and Lessons Learned in the Treatment of Transforming Small Cell Neuroendocrine Carcinoma of the Prostate: A Case Report and Literature Review.
1/2021Veliparib in combination with carboplatin/paclitaxel-based chemoradiotherapy in patients with stage III non-small cell lung cancer.
1/2018Phase I combination study of the PARP inhibitor veliparib plus carboplatin and gemcitabine in patients with advanced ovarian cancer and other solid malignancies.
4/2010Optimization of phenyl-substituted benzimidazole carboxamide poly(ADP-ribose) polymerase inhibitors: identification of (S)-2-(2-fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benzimidazole-4-carboxamide (A-966492), a highly potent and efficacious inhibitor.
1/2009Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer.
5/2007ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models.

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Yan Luo Research Topics

Disease

162Neoplasms (Cancer)
12/2024 - 04/2004
48Inflammation (Inflammations)
12/2024 - 03/2007
27Hepatocellular Carcinoma (Hepatoma)
11/2023 - 03/2006
26Breast Neoplasms (Breast Cancer)
02/2024 - 03/2006
25Neoplasm Metastasis (Metastasis)
02/2024 - 12/2004
24Infections
05/2024 - 12/2010
18Body Weight (Weight, Body)
12/2023 - 03/2009
18Non-alcoholic Fatty Liver Disease
01/2023 - 10/2013
15Fibrosis (Cirrhosis)
09/2023 - 07/2011
13Adenocarcinoma of Lung
01/2024 - 10/2004
12Carcinoma (Carcinomatosis)
05/2024 - 05/2007
12Diabetic Retinopathy (Retinopathy, Diabetic)
10/2022 - 03/2009
11Wounds and Injuries (Trauma)
12/2023 - 05/2000
11Hypoxia (Hypoxemia)
07/2023 - 03/2009
10Liver Cirrhosis (Hepatic Cirrhosis)
01/2024 - 01/2016
10Carcinogenesis
11/2023 - 04/2005
9Pain (Aches)
04/2024 - 01/2010
9COVID-19
03/2024 - 01/2020
9Lung Neoplasms (Lung Cancer)
12/2021 - 10/2004
8Obesity
01/2023 - 01/2016
8Sepsis (Septicemia)
01/2023 - 05/2015
8Prostatic Neoplasms (Prostate Cancer)
03/2022 - 10/2006
8Melanoma (Melanoma, Malignant)
04/2010 - 03/2006
7Ovarian Neoplasms (Ovarian Cancer)
05/2024 - 12/2017
7Necrosis
04/2024 - 06/2008
7Glaucoma
03/2024 - 03/2010
7Neurodegenerative Diseases (Neurodegenerative Disease)
02/2024 - 06/2009
7Colorectal Neoplasms (Colorectal Cancer)
04/2023 - 01/2014
7Ischemia
01/2013 - 09/2006
6Disease Progression
02/2024 - 05/2013
6Neuroinflammatory Diseases
02/2024 - 12/2016
6Insulin Resistance
12/2023 - 12/2017
6Cognitive Dysfunction
02/2023 - 05/2015
6Liver Neoplasms (Liver Cancer)
08/2022 - 10/2017
5Pancreatic Neoplasms (Pancreatic Cancer)
04/2024 - 11/2008
5Renal Cell Carcinoma (Grawitz Tumor)
04/2024 - 05/2016
5Retinal Neovascularization
07/2023 - 01/2010
5HIV Infections (HIV Infection)
06/2023 - 11/2011
5Rheumatoid Arthritis
06/2023 - 11/2006
5Psoriasis (Pustulosis Palmaris et Plantaris)
01/2023 - 01/2020
5Uterine Cervical Neoplasms (Cancer of the Cervix)
01/2023 - 12/2014
5Fatty Liver
10/2022 - 01/2020
5Alzheimer Disease (Alzheimer's Disease)
01/2022 - 01/2015
5B-Cell Lymphoma (Lymphoma, B Cell)
12/2021 - 12/2017
5Thrombosis (Thrombus)
05/2021 - 09/2007
5Rhabdomyosarcoma
01/2021 - 05/2010
5Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2021 - 11/2012

Drug/Important Bio-Agent (IBA)

44Proteins (Proteins, Gene)FDA Link
05/2024 - 11/2004
31Biomarkers (Surrogate Marker)IBA
12/2024 - 01/2016
23Retinaldehyde (Retinal)IBA
03/2024 - 06/2002
19Glucose (Dextrose)FDA LinkGeneric
12/2023 - 06/2005
16CytokinesIBA
12/2024 - 06/2011
15EnzymesIBA
12/2024 - 12/2007
15DNA (Deoxyribonucleic Acid)IBA
12/2024 - 09/2002
12AntigensIBA
12/2023 - 03/2006
12Messenger RNA (mRNA)IBA
11/2023 - 02/2011
12Phosphotransferases (Kinase)IBA
01/2023 - 09/2004
11Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
07/2023 - 02/2006
11Therapeutic UsesIBA
01/2022 - 07/2003
10VaccinesIBA
03/2024 - 03/2006
10CadmiumIBA
02/2024 - 03/2011
10Anti-Bacterial Agents (Antibiotics)IBA
11/2023 - 01/2012
10Long Noncoding RNAIBA
10/2023 - 01/2018
9LipopolysaccharidesIBA
05/2024 - 09/2015
9Cisplatin (Platino)FDA LinkGeneric
03/2023 - 05/2007
9veliparibIBA
01/2021 - 05/2007
8LipidsIBA
07/2021 - 05/2005
8Temozolomide (Temodar)FDA LinkGeneric
04/2010 - 05/2007
7Interleukin-6 (Interleukin 6)IBA
04/2024 - 01/2013
7Oxygen (Dioxygen)IBA
07/2023 - 07/2010
7Lactic Acid (Lactate)FDA LinkGeneric
07/2023 - 05/2014
7Peptides (Polypeptides)IBA
06/2023 - 08/2010
7Caspase 3 (Caspase-3)IBA
01/2022 - 01/2011
7CholesterolIBA
01/2022 - 01/2016
7Poly(ADP-ribose) Polymerase InhibitorsIBA
01/2018 - 05/2007
6RNA (Ribonucleic Acid)IBA
05/2024 - 09/2012
6Carboplatin (JM8)FDA LinkGeneric
01/2024 - 05/2007
6MicroRNAs (MicroRNA)IBA
12/2022 - 01/2017
6InterleukinsIBA
09/2022 - 04/2012
6MicellesIBA
01/2022 - 01/2016
6Sirolimus (Rapamycin)FDA Link
08/2021 - 09/2004
6Paclitaxel (Taxol)FDA LinkGeneric
01/2021 - 06/2005
6CurcuminIBA
01/2020 - 05/2005
6Small Interfering RNA (siRNA)IBA
01/2019 - 11/2004
5artenimol (dihydroartemisinin)IBA
02/2024 - 01/2014
5LDL CholesterolIBA
01/2023 - 05/2005
5Transcription Factors (Transcription Factor)IBA
01/2022 - 09/2002
5Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA
01/2022 - 03/2006
4Nuclear Proteins (Protein, Nuclear)IBA
04/2024 - 12/2015
4Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
03/2024 - 03/2006
4Monoclonal AntibodiesIBA
03/2024 - 12/2020
4Antiviral Agents (Antivirals)IBA
03/2024 - 02/2019

Therapy/Procedure

62Therapeutics
12/2024 - 04/2005
18Drug Therapy (Chemotherapy)
01/2024 - 06/2005
8Immunotherapy
12/2024 - 03/2006
8Liver Transplantation
12/2017 - 12/2003
6Radiotherapy
06/2023 - 10/2008
6Hepatectomy
05/2021 - 07/2008
5Transplantation
11/2023 - 03/2014
5Vitrectomy
01/2020 - 09/2002